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许明清

特别研究员

  • 电话:+86-021-62933378 Extension 8002
  • 邮箱:mingqingxu@sjtu.edu.cn
  • 地址:上海市华山路1954号基因组学楼212室
  • 实验室网址:http://www.bio-x.cn
  • 许博士从事统计学、机器学习、工程方法和生物医学问题相结合的交叉科学研究,主要研究方向包括:1)生物医学多组学、大数据的统计推断和数据挖掘;2)单基因疾病和衰老、神经精神疾病、癌症等遗传和表观遗传学基础;3)系统生物学与合成生物学;4)单分子操作和纳米技术在生物医学研究中的应用。

学术经历

  • 学士(1995-1999)  东北大学
  • 硕士(1999-2002)  上海大学
  • 博士(2002-2006)  ebet
  • 博士后(2006-2011)  美国哈佛大学
  • 现任《BMC Medical Genomics》副主编,《PLOS ONE》、《Scientific Reports》,《ExperimentalBiology and Medicine》,《Progress in Neuro-Psychopharmacology and Biological Psychiatry》编委。

研究方向

生物统计和机器学习

生物统计和机器学习,组学大数据,系统流行病学

生物信息学和系统生物学

生物信息学组学数据分析和算法,数据库开发,系统生物学研究基因型和表型的关系

单基因疾病和复杂疾病的分子机制

符合孟德尔遗传的单基因疾病,和癌症,器官和个体衰老,重大脑疾病等复杂疾病的遗传基础和分子机制

代表论著

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    Xirui Wang, Xianting Jiao, Bin Wang, Juan Li, Fan Yang, Lishan Zhang, Lei Xu, Mingqing Xu*, Xiaodan Yu*. Effects of circulating vitamin D levels on emotion, behavior and attention: A cross-sectional study in preschool children with follow-up behavior experiments in juvenile mice. Journal of Affective Disorders. In Press

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    Chen J#, Zhao X#, Cui L#, He G, Wang X, Wang F, Duan S, He L, Li Q, Zhang F, Yu X*, Xu M*. Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders. Aging (Albany NY). 2020 May 11;12(9):8434-8458. doi: 10.18632/aging.103150.

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    Jin G#, Xu M#, Zou M, Duan S. The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review. Mol Ther Nucleic Acids. 2020 Feb 8;20:13-24. doi: 10.1016/j.omtn.2020.01.037. 

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    Liu M, Li F, Yan H, Wang K, Ma Y; Alzheimer’s Disease Neuroimaging Initiative, Shen L, Xu M*. A multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in Alzheimer's disease. Neuroimage. 2020 Mar;208:116459. doi: 10.1016/j.neuroimage.2019.116459.

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    Li H#, Wang X#, Lu X, Zhu H, Li S, Duan S, Zhao X, Zhang F, Alterovitz G, Wang F, Li Q, Tian XL*, Xu M*. Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. Aging (Albany NY). 2019 Sep 12;11(18):7620-7638. doi: 10.18632/aging.102275.

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    Zheng S, Zhao T, Yuan S, Yang L, Ding J, Cui L*, Xu M*. Immunodeficiency Promotes Adaptive Alterations of Host Gut Microbiome: An Observational Metagenomic Study in Mice. Front Microbiol. 2019 Nov 1;10:2415. doi: 10.3389/fmicb.2019.02415.

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    Jiang L, Wang K, Lo K, Zhong Y, Yang A, Fang X, Akezhuoli H, Song Z, Chen L, An P, Xu M*, Min J*, Wang F*. Sex-Specific Association of Circulating Ferritin Level and Risk of Type 2 Diabetes: A Dose-Response Meta-Analysis of Prospective Studies. J Clin Endocrinol Metab. 2019 Oct 1;104(10):4539-4551. doi: 10.1210/jc.2019-00495.PMID: 31074789

教学情况

  • 上海市优秀博士论文奖
  • 全国优秀博士论文提名奖
  • ebetBio-X奖