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Xizhi Guo

Distinguished Professor

  • Tel: +86-021-34206736
  • Email: xzguo2005@sjtu.edu.cn
  • Address: #800 Dongchuan Road, Bldg#1-205, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China

Research Interests

Bone development and remodeling

  Using genetic knockout mice as animal models, we investigated into the molecular mechanism underlying the bone development and remodeling, which involves the coupling of osteoblast and osteoclast differentiation processes. Our research would provide novel insights into the therapeutic strategies of degenerative bone diseases, such as osteoporosis and osteoarthritis.  

Senescence of Mesenchymal Stem Cell

   The senescence of mesenchymal stem cells underlies a variety of aging-related diseases. Recently it is a prevaling strategy to treat these diaseases with senolytic method. We have revealed Foxp1 as a transcription factor in regulating senescence of mesenchymal stem cells(MSC), which is a potential target for the treatment of aging diseases.  

Adipose metabolism, obesity and diabetes

   Obesity and related diabetes are one of the plagues of our properity time.  We are going to explore the mechanisms of the development of obesity and diabetes from the prespectives of human evolution, alterations of human genome structure and life styles.   

Selected Publications

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    Foxp2 regulates anatomical features that may be relevant for vocal behavior and bipedal locomotion. 

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    Foxp1 controls cell fate commitment and senescence of mesenchymal stem cells during skeletal aging

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    Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors

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    Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than HSC maintenance.

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    Foxp1/2/4 regulate endochondral ossification as a suppresser complex.

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    Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. 

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    Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells.

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    Wnts-mediated reciprocal regulation between cartilage and bone development during endochondral ossification.

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    Ndrg2 regulates vertebral specification in differentiating somites. 

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    Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis.